vitamins [rate]

Before searching for the vitamin that can modulate innate as well as adaptive immunity of your body you must have brief information about the importance of immunity and its two kinds.

The immunity system of a body is a collection of tissues, molecules and cells that keep your body safe from the attack of pathogenic toxins and microbes found in the atmosphere. It defends your body from microbes through two types of reactions- reaction of innate immunity and reaction of adaptive immunity. Though both of these reactions are different from each other on the basis of the type of their effective cells, their response frequency to the microbes of different classes and duration of response to the pathogens. Both are equally important to the immune system.

The innate immune system of a body contains the proteins and cells always present in the body to fight at the sight of infection with the activated microbes. Phagocytic leukocytes, physical epithelial barriers, a natural killer or NK cell, a special type of lymphocyte, and circulating plasma proteins and dendritic cells are some of the components included in innate immune system.

Alternatively the adaptive immune system acts against the pathogens which can overcome or evade the defences for innate immune. Most of the components of the adaptive immune system normally remain silent but when activated they adapt to the existing infectious agents by proliferating, creating and activating the powerful mechanisms for eliminating or neutralizing the microbes present there.

Though there are a number of elements that can help in modulating innate and adaptive immunity in the body including macronutrients like dietary lipids and proteins and micronutrients like probiotics, minerals (iron, copper, selenium and zinc etc.) and vitamins (vitamin A, folate, B6, B12, C, D and E etc.) but vitamin D is considered as the best option for this purpose.

Traditionally Vitamin D is known for its role in the maintenance of the mineral density of your bones but now it is also considered important for influencing the immune system of a body as it regulates its inflammatory flow as well as modulates innate immunity and adaptive immunity.

Vitamin D3

Vitamin D and Innate Immunity

As per various researches, it has been proven that the cells like DCs and macrophages or monocytes focus on using vitamin D circulating in the system for activating intracrine. After getting activated, these cells focus on regulating the expression of genes and modulate the function of certain cells after inhibiting their maturation.

Vitamin D and Adaptive Immunity

The synthesis of calcitriol found in circulating vitamin D in your body is important for the immune response of both the cells, B-cells and T-cells. The activated DCs encourage intracellular activation of Vitamin D, which inhibits the maturation of DCs through intracrine activity. Thus the paracrine and intracrine actions of the vitamin D allow the modulation and induction of initial response.

In this way Vitamin D helps in modulating both innate and adaptive immunity.

 

 

References

http://missinglink.ucsf.edu/lm/immunology_module/prologue/objectives/obj02.html

http://www.ncbi.nlm.nih.gov/pubmed/25803545

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377899/