Brain Nutrition vitamins [rate]

Anxiety, Stress And Natural Remedy GABA

Anxiety is a normal response that prepares body to fight with the stressful condition. Medically it is known as a “fight to flight” response. Normally body comes to natural calm state once the stressful condition has passed out. But if the stress in not relieved after some time period, body is continuously under fight to flight response which exhausts the person mentally as well as physically leading to diseases called anxiety disorders.

Today anxiety disorders have become the global epidemic because of ever increasing stressful life style. Statistical analysis shows that the prevalence of anxiety disorders is higher among adults aged between 30-60 years, which is the most stressful period during anyone’s life.

Symptoms of anxiety are tension, confusion, agitation, irritability, phobia and lack of concentration. If not controlled earlier it can lead to fatal conditions like heart failure, heart attack and stroke.

Numbers of pharmaceutical and neutraceutical industries have gained advantages by providing the products that have the capabilities to reduce the anxiety by calming the brain. Most of these products use GABA (gamma amino butaric acid) or herbs that are source of GABA as an active ingredient in their products. This article will provide information about the mechanism by which GABA calms down the brain.

What is GABA?

GABA is an inhibitory neurotransmitter that calms down the brain by relaxing the nerve fibres. It is present naturally in all mammals. It blocks the nerve transmission leading to decreased activity of overly excited brain leading to focused and calmed approach to the stressful condition. To understand the mechanism by which GABA shows such activity, it is necessary to know how nerve fibres transmit the message of brain.

Process of nerve transmission

The massage of brain to the body parts is transmitted by nerve fibres that are present in the brain, spinal cord and peripheral organs. Nerve works like electric wires, but they have a space between every consecutive fibre. This is known as the synapse. The excited nerve fibre releases a chemical called neurotransmitter in the synapse which either excites or calms down the next fibre. Depending on their nature these neurotransmitters are categorized in two categories viz, excitatory and inhibitory neurotransmitters. Excitatory neurotransmitters (NMDA, glutamate) facilitate the nerve transmission, whereas inhibitory neurotransmitters (GABA, glycine) inhibit the nerve transmission. A balance between these two types of neurotransmitter is required to maintain the normal functioning of nerve transmission.

How GABA helps in relieving anxiety?

During anxiety balance of neurotransmitter is shifted towards the excitatory neurotransmitters that keep the body in excited state. During excited state the thinking and problem solvein capacities are decreased which puts more stress on the person’s brain. Thus if not checked, anxiety can initiate the vicious cycle of stress and anxiety.

GABA normalizes the balance of excitatory and inhibitory neurotransmitters in such excited states. Once in the body GABA reaches to the synapse where it binds to the GABA receptors that are present on the surface of nerve fibres. Bonding of GABA to GABA receptors release chloride ions in the nerve fibres. Chloride ions carry negative charge
which normalizes the positive charge of massage carrying nerve fibres. Thus, GABA reduces the excitation of nerve fibres leading to cool and calm brain.